Well, last week I had carpal tunnel surgery on my mouse hand. I doubt that it was caused by this though.
LR just really is awful for P45+ files sort of ok for M8 files if you tweak the color, not very good for D3 files, but pretty good for D200.
Unless Adobe gets better on the raw side, I don't see any hope. I try to keep the same file structure no matter what processor I am using, and so far, the only one that screws with it is C1. Instead of keeping state in a database or side-car files like LR, C1 scatters this all over the place. If you delete those files, your state goes away. I had C1 so confused after one file cleanup, in my photo directory space, that it would not start.
-bob