I've done both handheld and tripod MFD panos...just a few. Lack of opportunity, rather than lack of inspiration!
One slightly unusual thing I've done is to mount the camera on an Astrotrac, so that the stars are pinpoints rather than trails in deep twilight horizon shots. Aiming the frames of the pano is trickier in this case, as the camera sits above a tilted platform whose alignment towards the celestial pole must be preserved.
Another unusual thing I've done is a handheld infrared stitch. For fast handheld shutter speeds in the IR, you need a DB whose IR-cut filter can be trivially removed (Kodak DCS, Mamiya ZD), or which has no IR-cut filter at all (a few custom Phase One & Leaf "full spectrum colour" and "Achromatic" variants). I use a Kodak DCS645M.
I use Hugin to stitch - really excellent free software. It does amazingly accurate automatic lens profiling; I haven't seen any of the sort of residual vignetting that jagsiva drew attention to above.
Late 2012 Mac Mini: 2.6 GHz quad-core i7, 16GB 1600MHz RAM, 1.12TB Fusion Drive [1TB HDD with 128GB SSD]