My last project was done in the same huge wood tripod I use for my large format gear, everything composed and focused with live view and shutter released with the mirror up. I'm printing the project 40" and 60" wide. Other photographers have asked if the work had been done with 8x10.
But the camera has a couple of problems for me. One is terrible live-view performance, especially in low light. It's like trying to watch Earth TV from some far away galaxy. Very challenging for me to focus. The other is that I get a lot of digital artifacts in my images—overly strong edges on high contrast borders, jagged diagonal lines, and what sometimes looks like exaggerated chromatic aberration (but isn't). None of this is the standard aliasing artifacts from high spatial resolutions, but I believe it's somehow related to image detail around the nyquist frequency. I'm guessing that 20% or 25% more linear resolution could save me a lot of photoshop work. Although I don't know for sure.
At any rate, all else equal, more pixels would help me a bit. My sensor outperforms my lenses in the corners but not in the middle.
I also wish Nikon would send their UX engineers back to school. But who doesn't.