Be vewwy vewwy careful ... :ROTFL:
Actually I don't think it's that big of a deal unless you're using the ground glass a lot actually. I confess I'm a relative newbie at the technical camera but didn't have any problems getting into the rhythm of coarse adjustment, GG/loupe with hood on, open the shutter completely, compose, focus, compose & focus some more, remove the GG, mount the back & plug the cable in, close the shutter, set the desired aperture, meter the scene with a handmeter or cheat and use your DSLR, set the exposure, cock the shutter, remember to turn the back on (!!), release the shutter, squint at the dim LCD and check the histogram, correct as necessary, shoot again, open up the shutter a couple of stops, shoot the LCC card, forget to close the shutter down again and shoot +2 overexposed on the next shot .. duh, and so on. And that's without a wake up cable.
Well, that's my experience anyway.
Once you get as far as the base exposure it then easy to repeat the last steps with any rise/shift etc and multiple images.
It's been a few years since I last shot LF so I'm still forgetting to recock the shutter at times.
With respect to taking the back on & off, I always put the cover back on it and never leave it with the sensor bare. Ditto with the GG too when I put that back in the bag. Try to minimize the time the back is exposed and take care to make sure that the bottom of the sensor mount board is securely in the slot/fingers before tilting up to lock. I also recommend not playing the GG off with the left hand, back on with the right shuffle either. That's almost how I screwed up - it's worth the effort of using both hands!
I don't know the Flexbody/Hasselblad configuration but with the Alpa the back is already mounted on the sensor board so any damage/wear ultimately would come from mounting/unmounting that vs the actual back / board. I only took mine off the mount at the end of the day and vice versa. (That's where you need to be careful in my limited experience, just as you would with your regular camera).