During the take there are several things you can try, defocussing is one of the last I would try.
1) Change your perspective and distance somewhat
2) Try another f-stop
3) Go beyond f16 to introduce diffraction which you can counteract with a bit more aggressive sharpening. I would go this way before defocussing.
4) Try the same perspective but a bit wider lens, can only be done if you have enough pixels to crop away whatever you have too much.
5) The very best is to use multishot and even than I sometimes have moire. I actually use moire in the single shot to know for sure that the sharpness is where I want it. What has moire is definitely sharp
Every multishot take has an accompanying single shot.
6) In post processing I use the Phocus moire tool and export to layered PSD. I sure hope they will finally introduce being able to do much more aggressive moire reduction and exporting to layered PSD with a black mask on top of the layer with moire reduction!
7) In PS you can blur on another layer and put it to color
8) Select the color you need and use the color replacement brush to brush it in which works very fast as well.
There are a bunch of other methods I can think of that could be of help but the best way to go is not get it in the first place.