I see various threads about moving from heavy MF gear to crop MF and even to 35mm FF. Understandable. there are lots of applications in which manipulating a boat anchor is impractical. However, I am really impressed with my IQ4 back and, for most of what I do (fully manual, studio), there is no substitute for full size MF and the spectacular lenses that go with it. That's my answer to the OP of this thread. You will make compromises if the 250 you give up is your only full size camera. Only you know if those matter.
That said, I can't carry around a major MF rig while I stroll about or walk the dog. I'm too old and lazy and the dog makes a lousy tripod. I enjoy MF and I don't have to (couldn't) make a living at photography so MF it is for both studio and strolling. Therefore, I am about to add a lighter crop kit. Seems like a golden age for that, what with the GFX100s, the XCD2, and the new GFX100 coming momentarily. Leica, I understand, will introduce a mirrorless S4 sometime in the next year. A few years ago, a compact MF kit would have seemed very far off, but now we have options. Amazing, all things considered.