Given that we're doing photography and not mission-critical statistics I suspect a good solution can be had within the constraint of 10-20 frames worth of data.
I'm no expert in these matters, to be sure, but I've been blending multiple files into one to enhance image quality for many years now and many hundreds, if not thousands of photos, and I agree that a fairly small number of frames is sufficient for most purposes.
To reduce noise, increase SNR, and eliminate motion effects in a photo -- the primary benefits to be achieved by blending files for a typical stills photographer -- it's
not necessary to blend hundreds or thousands of files into one.
That's only necessary for astronomers, who aren't trying to reduce noise or increase the effective SNR of their camera's sensor, as much as they are trying increase the total amount of light that is gathered when taking a photo, which is another matter altogether.
As usually is the case with most things, at some point, as the number of frames being blended increases, the benefits that result from blending them will begin to diminish with each additional frame.
(As I noted in another thread, I find seven files to be a good compromise for
my long-exposure nighttime photos. That's because standing around, twiddling my thumbs while waiting on my camera for any longer than,say, 5 to 7 minutes, begins to reduce the fun of photography for me, even if doing so might result in a very slight improvement in the quality of the final, finished photos. Of course, this will be much less of an issue when using significantly shorter exposures for daytime photography, but everyone will need to determine where to draw that line for themselves...)
Of course you could do this with any number, not just 10, and I assume it would be smarter to use an odd number.
For some modes of blending, such as mean or averaging, it doesn't matter how many files are blended or whether the number of files is even or odd. However, because the median value of a sorted list of numbers is the middle value, when blending in median mode, blending an odd number of files is preferred.
Otherwise, the software will have to calculate the median value for each pixel by averaging the middle two values and this potentially means every pixel value of the final, blended file could, in effect, be made up instead of being selected from among the range of real values that were actually recorded. While this may not matter very much in practice, in theory, at least, blending an odd number of files is preferred, if only to preserve the already tenuous connection between the pixels captured by the camera and those used to create the finished photo.